Biological Psychiatry, 79, 887-897.The originality of the ACTIVMETER from Bioseb lies in its ability to quantify 3 parameters of animal behaviour:Īmong other advantages, this actimeter is characterized by Low dopamine D2 receptor increases vulnerability to obesity via reduced physical activity, not increased appetitive motivation. Chronic psychosocial stress persistently alters autonomic function and physical activity in mice. (11)70072-2īartolomucci, A., Palanza, P., Costoli, T., Savani, E., Laviola, G., Parmigiani, S., & Sgoifo, A. The projected effect of risk factor reduction on Alzheimer's disease prevalence. Adult neurogenesis conserves hippocampal memory capacity. J., Kitamura, T., Saitoh, Y., Ohkawa, N., Kondo, T., & Inokuchi, K. Frontiers in Behavioral Neuroscience, 9, 324. Comprehensive behavioral analysis of male Ox1r−/− mice showed implication of orexin receptor-1 in mood, anxiety, and social behavior. G., Shoji, H., Soya, S., Hondo, M., Miyakawa, T., & Sakurai, T. Experimental Physiology © 2021 The Physiological Society.Ībbas, M. Our results demonstrate that social isolation is a direct determinant of decreased physical activity, possibly because of reduced vigorous physical activity.Īctimeter hippocampal neurogenesis home-cage activity physical activity social isolation. Contrary to expectations, social isolation did not impair hippocampal neurogenesis. Furthermore, the reduction in the number of 5 min epochs during which the activity count exceeded 301 (an index of vigorous activity) was significantly larger for isolated mice. Home-cage activity in isolated mice during the dark period decreased by 26% from pre-intervention to the last week of intervention. Home-cage activity was measured for an additional 4 weeks. In the main experiment, after the 1 week baseline measurement performed with mice in group housing, the mice were placed in a group or in isolation. Although nanotag implantation decreased home-cage activity temporarily, at 7 days postimplantation the activity recovered to the same level as that of control (non-implanted) mice, suggesting that implantation of nanotag does not have a negative influence on home-cage activity if mice undergo a 1 week recovery period after implantation. Initially, we examined the influence of the intraperitoneal implantation of nanotag on home-cage activity. This study used a body-implantable actimeter called nanotag, which enabled us to measure home-cage activity despite housing the mice in groups. Hence, we assessed whether social isolation decreases home-cage activity using a within-subjects design and examined the effects of social isolation on hippocampal neurogenesis in mice. Social isolation is associated with physical inactivity however, it remains uncertain whether social isolation is a direct determinant of decreased physical activity. This might have resulted from increased immobility and decreased vigorous activity, suggesting that avoidance of social isolation is important to prevention of physical inactivity.Īn inactive lifestyle can have a negative impact on physiological and mental health. Our results clearly demonstrated that social isolation decreased home-cage activity in mice. What is the central question of this study? It is generally recognized that social isolation is associated with physical inactivity, but is social isolation a direct determinant of decreased physical activity? What is the main finding and its importance? We conducted a within-subjects experiment with the aid of a body-implantable actimeter.
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